[object Object], [object Object], [object Object] et al.

Current Opinion in Biotechnology • 2015

[object Object], [object Object], [object Object] et al.

Chemical Communications • 2015

This work proves for the first time the bioelectrochemical production of butyrate from CO2 as a sole carbon source. The highest concentration of butyrate achieved was 20.2 mMC, with a maximum butyrate production rate of 1.82 mMC d(-1). The electrochemical characterisation demonstrated that the CO2 reduction to butyrate was hydrogen driven. Production of ethanol and butanol was also observed opening up the potential for biofuel production.

[object Object], [object Object], [object Object]

Energy Conversion and Management • 2018

[object Object], [object Object], [object Object] et al.

Frontiers in Microbiology • 2021

Methane is the final product of the anaerobic decomposition of organic matter. The conversion of organic matter to methane (methanogenesis) as a mechanism for energy conservation is exclusively attributed to the archaeal domain. Methane is oxidized by methanotrophic microorganisms using oxygen or alternative terminal electron acceptors. Aerobic methanotrophic bacteria belong to the phyla Proteobacteria and Verrucomicrobia, while anaerobic methane oxidation is also mediated by more recently discovered anaerobic methanotrophs with representatives in both the bacteria and the archaea domains. The anaerobic oxidation of methane is coupled to the reduction of nitrate, nitrite, iron, manganese, sulfate, and organic electron acceptors (e.g., humic substances) as terminal electron acceptors. This review highlights the relevance of methanotrophy in natural and anthropogenically influenced ecosystems, emphasizing the environmental conditions, distribution, function, co-existence, interactions, and the availability of electron acceptors that likely play a key role in regulating their function. A systematic overview of key aspects of ecology, physiology, metabolism, and genomics is crucial to understand the contribution of methanotrophs in the mitigation of methane efflux to the atmosphere. We give significance to the processes under microaerophilic and anaerobic conditions for both aerobic and anaerobic methane oxidizers. In the context of anthropogenically influenced ecosystems, we emphasize the current and potential future applications of methanotrophs from two different angles, namely methane mitigation in wastewater treatment through the application of anaerobic methanotrophs, and the biotechnological applications of aerobic methanotrophs in resource recovery from methane waste streams. Finally, we identify knowledge gaps that may lead to opportunities to harness further the biotechnological benefits of methanotrophs in methane mitigation and for the production of valuable bioproducts enabling a bio-based and circular economy.

[object Object], [object Object], [object Object] et al.

Environmental Science & Technology • 2015

High product specificity and production rate are regarded as key success parameters for large-scale applicability of a (bio)chemical reaction technology. Here, we report a significant performance enhancement in acetate formation from CO2, reaching comparable productivity levels as in industrial fermentation processes (volumetric production rate and product yield). A biocathode current density of -102 ± 1 A m(-2) and an acetic acid production rate of 685 ± 30 (g m(-2) day(-1)) have been achieved in this study. High recoveries of 94 ± 2% of the CO2 supplied as the sole carbon source and 100 ± 4% of electrons into the final product (acetic acid) were achieved after development of a mature biofilm, reaching an elevated product titer of up to 11 g L(-1). This high product specificity is remarkable for mixed microbial cultures, which would make the product downstream processing easier and the technology more attractive. This performance enhancement was enabled through the combination of a well-acclimatized and enriched microbial culture (very fast start-up after culture transfer), coupled with the use of a newly synthesized electrode material, EPD-3D. The throwing power of the electrophoretic deposition technique, a method suitable for large-scale production, was harnessed to form multiwalled carbon nanotube coatings onto reticulated vitreous carbon to generate a hierarchical porous structure.

[object Object]

Nano-Micro Letters • 2017

With the development of carbon nanomaterials in recent years, there has been an explosion of interests in using carbon nanotubes (CNTs) and graphene for developing new biosensors. It is believed that employing CNTs and graphene as sensor components can make sensors more reliable, accurate, and fast due to their remarkable properties. Depending on the types of target molecular, different strategies can be applied to design sensor device. This review article summarized the important progress in developing CNT- and graphene-based electrochemical biosensors, field-effect transistor biosensors, and optical biosensors. Although CNTs and graphene have led to some groundbreaking discoveries, challenges are still remained and the state-of-the-art sensors are far from a practical application. As a conclusion, future effort has to be made through an interdisciplinary platform, including materials science, biology, and electric engineering.

[object Object], [object Object], [object Object] et al.

Nature Communications • 2016

Microalgae and cyanobacteria are some of nature’s finest examples of solar energy conversion systems, effortlessly transforming inorganic carbon into complex molecules through photosynthesis. The efficiency of energy-dense hydrocarbon production by photosynthetic organisms is determined in part by the light collected by the microorganisms. Therefore, optical engineering has the potential to increase the productivity of algae cultivation systems used for industrial-scale biofuel synthesis. Herein, we explore and report emerging and promising material science and engineering innovations for augmenting microalgal photosynthesis. Photosynthetic microalgae could provide an ecologically sustainable route to produce solar biofuels and high-value chemicals. Here, the authors review various optical management strategies used to manipulate the incident light in order to increase the efficiency of microalgae biofuel production.

[object Object], [object Object], [object Object] et al.

Environmental Science & Technology • 2015

The advent of renewable energy conversion systems exacerbates the existing issue of intermittent excess power. Microbial electrosynthesis can use this power to capture CO2 and produce multicarbon compounds as a form of energy storage. As catalysts, microbial populations can be used, provided side reactions such as methanogenesis are avoided. Here a simple but effective approach is presented based on enrichment of a robust microbial community via several culture transfers with H2:CO2 conditions. This culture produced acetate at a concentration of 1.29 ± 0.15 g L(-1) (maximum up to 1.5 g L(-1); 25 mM) from CO2 at a fixed current of -5 Am(-2) in fed-batch bioelectrochemical reactors at high N2:CO2 flow rates. Continuous supply of reducing equivalents enabled acetate production at a rate of 19 ± 2 gm(-2)d(-1) (projected cathode area) in several independent experiments. This is a considerably high rate compared with other unmodified carbon-based cathodes. 58 ± 5% of the electrons was recovered in acetate, whereas 30 ± 10% of the electrons was recovered in H2 as a secondary product. The bioproduction was most likely H2 based; however, electrochemical, confocal microscopy, and community analyses of the cathodes suggested the possible involvement of the cathodic biofilm. Together, the enrichment approach and galvanostatic operation enabled instant start-up of the electrosynthesis process and reproducible acetate production profiles.

[object Object], [object Object], [object Object] et al.

Biotechnology Advances • 2015

[object Object], [object Object], [object Object] et al.

Chemical Engineering Journal • 2015

[object Object], [object Object]

Biotechnology for Biofuels • 2016

Extracellular electron transfer in microorganisms has been applied for bioelectrochemical synthesis utilizing microbes to catalyze anodic and/or cathodic biochemical reactions. Anodic reactions (electron transfer from microbe to anode) are used for current production and cathodic reactions (electron transfer from cathode to microbe) have recently been applied for current consumption for valuable biochemical production. The extensively studied exoelectrogenic bacteria Shewanella and Geobacter showed that both directions for electron transfer would be possible. It was proposed that gram-positive bacteria, in the absence of cytochrome C, would accept electrons using a cascade of membrane-bound complexes such as membrane-bound Fe-S proteins, oxidoreductase, and periplasmic enzymes. Modification of the cathode with the addition of positive charged species such as chitosan or with an increase of the interfacial area using a porous three-dimensional scaffold electrode led to increased current consumption. The extracellular electron transfer from the cathode to the microbe could catalyze various bioelectrochemical reductions. Electrofermentation used electrons from the cathode as reducing power to produce more reduced compounds such as alcohols than acids, shifting the metabolic pathway. Electrofuel could be generated through artificial photosynthesis using electrical energy instead of solar energy in the process of carbon fixation.

[object Object], [object Object], [object Object]

Chemical Society Reviews • 2020

reduction, and chemical synthesis more broadly. In the following section, we discuss the strategies to incorporate microorganisms in photocatalytic and (photo)electrochemical systems to produce fuels and chemicals with renewable sources. Finally, we outline emerging analytical techniques to study the bio-material hybrid systems and propose unexplored research opportunities in the field of semi-artificial photosynthesis.

[object Object], [object Object], [object Object] et al.

Journal of Pharmaceutical Sciences • 2018

[object Object], [object Object], [object Object] et al.

Molecular Plant-Microbe Interactions • 2015

Jasmonic acid (JA) is an essential hormone in plant development and defense responses in Arabidopsis thaliana. Exogenous treatment with JA has recently been shown to alter root exudate profiles and the composition of root-associated bacterial communities. However, it is currently unknown whether disruptions of the JA in the rhizosphere affect root exudation profiles and the relative abundance of bacteria and archaea in the rhizosphere. In the present study, two Arabidopsis mutants that are disrupted in different branches of the jasmonate pathway, namely myc2 and med25, were cultivated in nutrient solution and soil to profile root exudates and bacterial and archaeal communities, respectively. Compared with the wild type, both mutants showed distinct exudation patterns, including lower amounts of asparagine, ornithine, and tryptophan, as well as distinct bacterial and archaeal community composition, as illustrated by an increased abundance of Streptomyces, Bacillus, and Lysinibacillus taxa in the med25 rhizosphere and an Enterobacteriaceae population in myc2. Alternatively, the Clostridiales population was less abundant in the rhizosphere of both mutants. Similarities between plant genotypes were highly correlated, as determined by operational taxonomic units in the rhizosphere and metabolites in root exudates. This strongly suggests that root exudates play a major role in modulating changes in microbial community composition upon plant defense responses.

[object Object], [object Object], [object Object] et al.

Microbial Cell Factories • 2019

C-metabolic flux analysis of mixed culture metabolism and cross-feeding offers a computational approach to complement experimental research for improved consortia performance.

[object Object], [object Object], [object Object] et al.

Separation and Purification Technology • 2019

[object Object], [object Object]

ACS Sensors • 2017

Self-powered electrochemical biosensors utilize biofuel cells as a simultaneous power source and biosensor, which simplifies the biosensor system, because it no longer requires a potentiostat, power for the potentiostat, and/or power for the signaling device. This review article is focused on detailing the advances in the field of self-powered biosensors and discussing their advantages and limitations compared to other types of electrochemical biosensors. The review will discuss self-powered biosensors formed from enzymatic biofuel cells, organelle-based biofuel cells, and microbial fuel cells. It also discusses the different mechanisms of sensing, including utilizing the analyte being the substrate/fuel for the biocatalyst, the analyte binding the biocatalyst to the electrode surface, the analyte being an inhibitor of the biocatalyst, the analyte resulting in the blocking of the bioelectrocatalytic response, the analyte reactivating the biocatalyst, Boolean logic gates, and combining affinity-based biorecognition elements with bioelectrocatalytic power generation. The final section of this review details areas of future investigation that are needed in the field, as well as problems that still need to be addressed by the field.

[object Object], [object Object], [object Object] et al.

Frontiers in Microbiology • 2016

Polyunsaturated fatty acids (PUFAs) of the ω-3 and ω-6 class (e.g., α-linolenic acid, linoleic acid) are essential for maintaining biofunctions in mammalians like humans. Due to the fact that humans cannot synthesize these essential fatty acids, they must be taken up from different food sources. Classical sources for these fatty acids are porcine liver and fish oil. However, microbial lipids or single cell oils, produced by oleaginous microorganisms such as algae, fungi and bacteria, are a promising source as well. These single cell oils can be used for many valuable chemicals with applications not only for nutrition but also for fuels and are therefore an ideal basis for a bio-based economy. A crucial point for the establishment of microbial lipids utilization is the cost-effective production and purification of fuels or products of higher value. The fermentative production can be realized by submerged (SmF) or solid state fermentation (SSF). The yield and the composition of the obtained microbial lipids depend on the type of fermentation and the particular conditions (e.g., medium, pH-value, temperature, aeration, nitrogen source). From an economical point of view, waste or by-product streams can be used as cheap and renewable carbon and nitrogen sources. In general, downstream processing costs are one of the major obstacles to be solved for full economic efficiency of microbial lipids. For the extraction of lipids from microbial biomass cell disruption is most important, because efficiency of cell disruption directly influences subsequent downstream operations and overall extraction efficiencies. A multitude of cell disruption and lipid extraction methods are available, conventional as well as newly emerging methods, which will be described and discussed in terms of large scale applicability, their potential in a modern biorefinery and their influence on product quality. Furthermore, an overview is given about applications of microbial lipids or derived fatty acids with emphasis on food applications.

[object Object], [object Object], [object Object] et al.

Advanced Science • 2015

and excellent durability.

[object Object], [object Object], [object Object] et al.

Environmental Science and Pollution Research • 2019

[object Object], [object Object], [object Object] et al.

Water • 2020

Dyes (colorants) are used in many industrial applications, and effluents of several industries contain toxic dyes. Dyes exhibit toxicity to humans, aquatic organisms, and the environment. Therefore, dyes containing wastewater must be properly treated before discharging to the surrounding water bodies. Among several water treatment technologies, adsorption is the most preferred technique to sequester dyes from water bodies. Many studies have reported the removal of dyes from wastewater using biochar produced from different biomass, e.g., algae and plant biomass, forest, and domestic residues, animal waste, sewage sludge, etc. The aim of this review is to provide an overview of the application of biochar as an eco-friendly and economical adsorbent to remove toxic colorants (dyes) from the aqueous environment. This review highlights the routes of biochar production, such as hydrothermal carbonization, pyrolysis, and hydrothermal liquefaction. Biochar as an adsorbent possesses numerous advantages, such as being eco-friendly, low-cost, and easy to use; various precursors are available in abundance to be converted into biochar, it also has recyclability potential and higher adsorption capacity than other conventional adsorbents. From the literature review, it is clear that biochar is a vital candidate for removal of dyes from wastewater with adsorption capacity of above 80%.

[object Object], [object Object], [object Object] et al.

The Lancet Infectious Diseases • 2022

BACKGROUND: The global burden of lower respiratory infections (LRIs) and corresponding risk factors in children older than 5 years and adults has not been studied as comprehensively as it has been in children younger than 5 years. We assessed the burden and trends of LRIs and risk factors across all age groups by sex, for 204 countries and territories. METHODS: In this analysis of data for the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we used clinician-diagnosed pneumonia or bronchiolitis as our case definition for LRIs. We included International Classification of Diseases 9th edition codes 079.6, 466-469, 470.0, 480-482.8, 483.0-483.9, 484.1-484.2, 484.6-484.7, and 487-489 and International Classification of Diseases 10th edition codes A48.1, A70, B97.4-B97.6, J09-J15.8, J16-J16.9, J20-J21.9, J91.0, P23.0-P23.4, and U04-U04.9. We used the Cause of Death Ensemble modelling strategy to analyse 23 109 site-years of vital registration data, 825 site-years of sample vital registration data, 1766 site-years of verbal autopsy data, and 681 site-years of mortality surveillance data. We used DisMod-MR 2.1, a Bayesian meta-regression tool, to analyse age-sex-specific incidence and prevalence data identified via systematic reviews of the literature, population-based survey data, and claims and inpatient data. Additionally, we estimated age-sex-specific LRI mortality that is attributable to the independent effects of 14 risk factors. FINDINGS: Globally, in 2019, we estimated that there were 257 million (95% uncertainty interval [UI] 240-275) LRI incident episodes in males and 232 million (217-248) in females. In the same year, LRIs accounted for 1·30 million (95% UI 1·18-1·42) male deaths and 1·20 million (1·07-1·33) female deaths. Age-standardised incidence and mortality rates were 1·17 times (95% UI 1·16-1·18) and 1·31 times (95% UI 1·23-1·41) greater in males than in females in 2019. Between 1990 and 2019, LRI incidence and mortality rates declined at different rates across age groups and an increase in LRI episodes and deaths was estimated among all adult age groups, with males aged 70 years and older having the highest increase in LRI episodes (126·0% [95% UI 121·4-131·1]) and deaths (100·0% [83·4-115·9]). During the same period, LRI episodes and deaths in children younger than 15 years were estimated to have decreased, and the greatest decline was observed for LRI deaths in males younger than 5 years (-70·7% [-77·2 to -61·8]). The leading risk factors for LRI mortality varied across age groups and sex. More than half of global LRI deaths in children younger than 5 years were attributable to child wasting (population attributable fraction [PAF] 53·0% [95% UI 37·7-61·8] in males and 56·4% [40·7-65·1] in females), and more than a quarter of LRI deaths among those aged 5-14 years were attributable to household air pollution (PAF 26·0% [95% UI 16·6-35·5] for males and PAF 25·8% [16·3-35·4] for females). PAFs of male LRI deaths attributed to smoking were 20·4% (95% UI 15·4-25·2) in those aged 15-49 years, 30·5% (24·1-36·9) in those aged 50-69 years, and 21·9% (16·8-27·3) in those aged 70 years and older. PAFs of female LRI deaths attributed to household air pollution were 21·1% (95% UI 14·5-27·9) in those aged 15-49 years and 18·2% (12·5-24·5) in those aged 50-69 years. For females aged 70 years and older, the leading risk factor, ambient particulate matter, was responsible for 11·7% (95% UI 8·2-15·8) of LRI deaths. INTERPRETATION: The patterns and progress in reducing the burden of LRIs and key risk factors for mortality varied across age groups and sexes. The progress seen in children younger than 5 years was clearly a result of targeted interventions, such as vaccination and reduction of exposure to risk factors. Similar interventions for other age groups could contribute to the achievement of multiple Sustainable Development Goals targets, including promoting wellbeing at all ages and reducing health inequalities. Interventions, including addressing risk factors such as child wasting, smoking, ambient particulate matter pollution, and household air pollution, would prevent deaths and reduce health disparities. FUNDING: Bill & Melinda Gates Foundation.

[object Object], [object Object], [object Object]

Agrochemicals • 2023

In an alarming tale of agricultural excess, the relentless overuse of chemical fertilizers in modern farming methods have wreaked havoc on the once-fertile soil, mercilessly depleting its vital nutrients while inflicting irreparable harm on the delicate balance of the surrounding ecosystem. The excessive use of such fertilizers leaves residue on agricultural products, pollutes the environment, upsets agrarian ecosystems, and lowers soil quality. Furthermore, a significant proportion of the nutrient content, including nitrogen, phosphorus, and potassium, is lost from the soil (50–70%) before being utilized. Nanofertilizers, on the other hand, use nanoparticles to control the release of nutrients, making them more efficient and cost-effective than traditional fertilizers. Nanofertilizers comprise one or more plant nutrients within nanoparticles where at least 50% of the particles are smaller than 100 nanometers. Carbon nanotubes, graphene, and quantum dots are some examples of the types of nanomaterials used in the production of nanofertilizers. Nanofertilizers are a new generation of fertilizers that utilize advanced nanotechnology to provide an efficient and sustainable method of fertilizing crops. They are designed to deliver plant nutrients in a controlled manner, ensuring that the nutrients are gradually released over an extended period, thus providing a steady supply of essential elements to the plants. The controlled-release system is more efficient than traditional fertilizers, as it reduces the need for frequent application and the amount of fertilizer. These nanomaterials have a high surface area-to-volume ratio, making them ideal for holding and releasing nutrients. Naturally occurring nanoparticles are found in various sources, including volcanic ash, ocean, and biological matter such as viruses and dust. However, regarding large-scale production, relying solely on naturally occurring nanoparticles may not be sufficient or practical. In agriculture, nanotechnology has been primarily used to increase crop production while minimizing losses and activating plant defense mechanisms against pests, insects, and other environmental challenges. Furthermore, nanofertilizers can reduce runoff and nutrient leaching into the environment, improving environmental sustainability. They can also improve fertilizer use efficiency, leading to higher crop yields and reducing the overall cost of fertilizer application. Nanofertilizers are especially beneficial in areas where traditional fertilizers are inefficient or ineffective. Nanofertilizers can provide a more efficient and cost-effective way to fertilize crops while reducing the environmental impact of fertilizer application. They are the product of promising new technology that can help to meet the increasing demand for food and improve agricultural sustainability. Currently, nanofertilizers face limitations, including higher costs of production and potential environmental and safety concerns due to the use of nanomaterials, while further research is needed to fully understand their long-term effects on soil health, crop growth, and the environment.

[object Object], [object Object], [object Object] et al.

Applied Water Science • 2022

In recent years, rapid development in the industrial sector has offered console to the people but at the same time, generates numerous amounts of effluent composed of toxic elements like nitrogen, phosphorus, hydrocarbons, and heavy metals that influences the environment and mankind hazardously. While the technological advancements are made in industrial effluent treatment, there arising stretch in the techniques directing on hybrid system that are effective in resource recovery from effluent in an economical, less time consuming and viable manner. The key objective of this article is to study, propose and deliberate the process and products obtained from different industries and the quantity of effluents produced, and the most advanced and ultra-modern theoretical and scientific improvements in treatment methods to remove those dissolved matter and toxic substances and also the challenges and perspectives in these developments. The findings of this review appraise new eco-friendly technologies, provide intuition into the efficiency in contaminants removal and aids in interpreting degradation mechanism of toxic elements by various treatment assemblages.

[object Object], [object Object], [object Object] et al.

Reviews in Environmental Science and Bio/Technology • 2017

Treatment of biowaste, the predominant waste fraction in low-and middle-income settings, offers public health, environmental and economic benefits by converting waste into a hygienic product, diverting it from disposal sites, and providing a source of income. This article presents a comprehensive overview of 13 biowaste treatment technologies, grouped into four categories: (1) direct use (direct land application, direct animal feed, direct combustion), (2) biological treatment (composting, vermicomposting, black soldier fly treatment, anaerobic digestion, fermentation), (3) physico-chemical treatment (transesterification, densification), and (4) thermo-chemical treatment (pyrolysis, liquefaction, gasification). Based on a literature review and expert consultation, the main feedstock requirements, process conditions and treatment products are summarized, and the challenges and trends, particularly regarding the applicability of each technology in the urban low-and middle-income context, are critically discussed. An analysis of the scientific articles published from 2005 to 2015 reveals substantial differences in the amount and type of research published for each technology, a fact that can partly be explained with the development stage of the technologies. Overall, publications from case studies and field research seem disproportionately underrepresented for all technologies. One may argue that this reflects the main task of researchers-to conduct fundamental research for enhanced process understanding-but it may also be a result of the traditional embedding of the waste sector in the discipline of engineering science, where socio-economic and management aspects are seldom object of the research. More unbiased, wellstructured and reproducible evidence from case studies at scale could foster the knowledge transfer to practitioners and enhance the exchange between academia, policy and practice.

[object Object], [object Object], [object Object] et al.

Current Opinion in Biotechnology • 2015

[object Object], [object Object], [object Object] et al.

BioMed Research International • 2015

The world energy crisis and increased greenhouse gas emissions have driven the search for alternative and environmentally friendly renewable energy sources. According to life cycle analysis, microalgae biofuel is identified as one of the major renewable energy sources for sustainable development, with potential to replace the fossil-based fuels. Microalgae biofuel was devoid of the major drawbacks associated with oil crops and lignocelluloses-based biofuels. Algae-based biofuels are technically and economically viable and cost competitive, require no additional lands, require minimal water use, and mitigate atmospheric CO2. However, commercial production of microalgae biodiesel is still not feasible due to the low biomass concentration and costly downstream processes. The viability of microalgae biodiesel production can be achieved by designing advanced photobioreactors, developing low cost technologies for biomass harvesting, drying, and oil extraction. Commercial production can also be accomplished by improving the genetic engineering strategies to control environmental stress conditions and by engineering metabolic pathways for high lipid production. In addition, new emerging technologies such as algal-bacterial interactions for enhancement of microalgae growth and lipid production are also explored. This review focuses mainly on the problems encountered in the commercial production of microalgae biofuels and the possible techniques to overcome these difficulties.

[object Object], [object Object], [object Object] et al.

Biosensors and Bioelectronics • 2019

[object Object], [object Object], [object Object] et al.

Scientific Reports • 2017

Over the present material synthesis routes, the sonochemical route is highly efficient and comfortable way to produce nanostructured materials. In this way, the copper sulfide (CuS-covellite) and sulfur doped reduced graphene oxide (S-rGO) nanocomposite was prepared by sonochemical method. Interestingly, the structure of the as-prepared S-rGO/CuS was changed from the covellite to digenite phase. Herein, the S-rGO was act as a mild oxidizer and liable for the structural transformations. These structural changes are sequentially studied by various physicochemical characterizations such as Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and Transmission electron microscopy (TEM). After scrupulous structural evaluations, the transformation of CuS phase was identified and documented. This oxidized CuS has an excellent electrocatalytic activity when compare to the bulk CuS. This S-rGO/CuS was further used for the determination of glucose and acquired good electrocatalytic performances. This S-rGO/CuS was exhibited a wide linear concentration range, 0.0001-3.88 mM and 3.88-20.17 mM, and a low-level detection limit of 32 nM. Moreover, we have validated the practicability of our developed glucose sensor in real biological samples.

[object Object], [object Object], [object Object] et al.

Journal of Hazardous Materials • 2018

Critical raw materials (CRMs) are essential in the development of novel high-tech applications. They are essential in sustainable materials and green technologies, including renewable energy, emissionfree electric vehicles and energy-efficient lighting. However, the sustainable supply of CRMs is a major concern. Recycling end-of-life devices is an integral element of the CRMs supply policy of many countries. Waste electrical and electronic equipment (WEEE) is an important secondary source of CRMs. Currently, pyrometallurgical processes are used to recycle metals from WEEE. These processes are deemed imperfect, energy-intensive and non-selective towards CRMs. Biotechnologies are a promising alternative to the current industrial best available technologies (BAT). In this review, we present the current frontiers in CRMs recovery from WEEE using biotechnology, the biochemical fundamentals of these bio-based technologies and discuss recent research and development (R&D) activities. These technologies encompass biologically induced leaching (bioleaching) from various matrices,biomass-induced sorption (biosorption), and bioelectrochemical systems (BES).

[object Object], [object Object], [object Object] et al.

Nature Metabolism • 2021

Ageing-associated functional decline of organs and increased risk for age-related chronic pathologies is driven in part by the accumulation of senescent cells, which develop the senescence-associated secretory phenotype (SASP). Here we show that procyanidin C1 (PCC1), a polyphenolic component of grape seed extract (GSE), increases the healthspan and lifespan of mice through its action on senescent cells. By screening a library of natural products, we find that GSE, and PCC1 as one of its active components, have specific effects on senescent cells. At low concentrations, PCC1 appears to inhibit SASP formation, whereas it selectively kills senescent cells at higher concentrations, possibly by promoting production of reactive oxygen species and mitochondrial dysfunction. In rodent models, PCC1 depletes senescent cells in a treatment-damaged tumour microenvironment and enhances therapeutic efficacy when co-administered with chemotherapy. Intermittent administration of PCC1 to either irradiated, senescent cell-implanted or naturally aged old mice alleviates physical dysfunction and prolongs survival. We identify PCC1 as a natural senotherapeutic agent with in vivo activity and high potential for further development as a clinical intervention to delay, alleviate or prevent age-related pathologies.

[object Object], [object Object], [object Object] et al.

Frontiers in Physiology • 2018

Deformability is an essential feature of blood cells (RBCs) that enables them to travel through even the smallest capillaries of the human body. Deformability is a function of (i) structural elements of cytoskeletal proteins, (ii) processes controlling intracellular ion and water handling and (iii) membrane surface-to-volume ratio. All these factors may be altered in various forms of hereditary hemolytic anemia, such as sickle cell disease, thalassemia, hereditary spherocytosis and hereditary xerocytosis. Although mutations are known as the primary causes of these congenital anemias, little is known about the resulting secondary processes that affect RBC deformability (such as secondary changes in RBC hydration, membrane protein phosphorylation, and RBC vesiculation). These secondary processes could, however, play an important role in the premature removal of the aberrant RBCs by the spleen. Altered RBC deformability could contribute to disease pathophysiology in various disorders of the RBC. Here we review the current knowledge on RBC deformability in different forms of hereditary hemolytic anemia and describe secondary mechanisms involved in RBC deformability.

[object Object], [object Object], [object Object] et al.

Advances in Colloid and Interface Science • 2022

[object Object], [object Object], [object Object]

Current Pollution Reports • 2015

[object Object], [object Object], [object Object] et al.

The Science of The Total Environment • 2018

[object Object], [object Object], [object Object]

Pharmaceutics • 2023

A biomarker is any measurable biological moiety that can be assessed and measured as a potential index of either normal or abnormal pathophysiology or pharmacological responses to some treatment regimen. Every tissue in the body has a distinct biomolecular make-up, which is known as its biomarkers, which possess particular features, viz., the levels or activities (the ability of a gene or protein to carry out a particular body function) of a gene, protein, or other biomolecules. A biomarker refers to some feature that can be objectively quantified by various biochemical samples and evaluates the exposure of an organism to normal or pathological procedures or their response to some drug interventions. An in-depth and comprehensive realization of the significance of these biomarkers becomes quite important for the efficient diagnosis of diseases and for providing the appropriate directions in case of multiple drug choices being presently available, which can benefit any patient. Presently, advancements in omics technologies have opened up new possibilities to obtain novel biomarkers of different types, employing genomic strategies, epigenetics, metabolomics, transcriptomics, lipid-based analysis, protein studies, etc. Particular biomarkers for specific diseases, their prognostic capabilities, and responses to therapeutic paradigms have been applied for screening of various normal healthy, as well as diseased, tissue or serum samples, and act as appreciable tools in pharmacology and therapeutics, etc. In this review, we have summarized various biomarker types, their classification, and monitoring and detection methods and strategies. Various analytical techniques and approaches of biomarkers have also been described along with various clinically applicable biomarker sensing techniques which have been developed in the recent past. A section has also been dedicated to the latest trends in the formulation and designing of nanotechnology-based biomarker sensing and detection developments in this field.

[object Object], [object Object], [object Object] et al.

Journal of Materials Chemistry A • 2018

From precursors to novel polymeric and ceramic coatings with tailored properties. The first review on coatings based on silicon preceramic polymers.

[object Object], [object Object], [object Object]

Frontiers in Plant Science • 2016

To survive in a saline environment, halophytes have evolved many strategies to resist salt stress. The salt glands of recretohalophytes are exceptional features for directly secreting salt out of a plant. Knowledge of the pathway(s) of salt secretion in relation to the function of salt glands may help us to change the salt-tolerance of crops and to cultivate the extensive saline lands that are available. Recently, ultrastructural studies of salt glands and the mechanism of salt secretion, particularly the candidate genes involved in salt secretion, have been illustrated in detail. In this review, we summarize current researches on salt gland structure, salt secretion mechanism and candidate genes involved, and provide an overview of the salt secretion pathway and the asymmetric ion transport of the salt gland. A new model recretohalophyte is also proposed.

[object Object], [object Object], [object Object] et al.

ACS Environmental Au • 2023

equiv/tonne FW) and economic (-100 to $138/tonne FW) impacts of FW depend on the multiple parameters of food chains and waste management systems. Although enormous efforts are underway to reduce FW as well as valorize unavoidable FW to reduce environmental and economic loss, it seems the transdisciplinary approach/initiative would be essential to minimize FW as well as abate the environmental impacts of FW. A joint effort from stakeholders is the key to reducing FW and the efficient and effective valorization of FW to improve its sustainability. However, any initiative in reducing food waste should consider a broader sustainability check to avoid risks to investment and the environment.

[object Object], [object Object], [object Object] et al.

Scientific Reports • 2015

The reductive dechlorination of pentachlorophenol (PCP) by Geobacter sulfurreducens in the presence of different biochars was investigated to understand how biochars affect the bioreduction of environmental contaminants. The results indicated that biochars significantly accelerate electron transfer from cells to PCP, thus enhancing reductive dechlorination. The promotion effects of biochar (as high as 24-fold) in this process depend on its electron exchange capacity (EEC) and electrical conductivity (EC). A kinetic model revealed that the surface redox-active moieties (RAMs) and EC of biochar (900 °C) contributed to 56% and 41% of the biodegradation rate, respectively. This work demonstrates that biochars are efficient electron mediators for the dechlorination of PCP and that both the EC and RAMs of biochars play important roles in the electron transfer process.